skip to Main Content

یک روش ترکیبی سلول درمانی و مهندسی بافت در محل برای ترمیم قلب

عنوان انگلیسی: A combined cell therapy and in-situ tissue-engineering approach for myocardial repair
سال نشر: ۲۰۱۱
نویسنده: Manhal Habib,Keren Shapira-Schweitzer,Oren Caspi,Amira Gepstein,Gil Arbel,Doron Aronson,Dror Seliktar,Lior Gepstein
تعداد صفحه فارسی: ۱۳ – تعداد صفحه انگلیسی: ۱۰
دانشگاه: Bruce Rappaport Faculty of Medicine and Technion-Israel Institute of Technology, Haifa, Israel b Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel
نشریه: Process Safety and Environmental Protection
کیفیت ترجمه: اقتصادی



Myocardial cell-replacement strategies are hampered by limited sources for human cardiomyocytes and by significant cell loss following transplantation. We tested the hypothesis that a combined delivery of cardiomyocytes with an in-situ polymerizable hydrogel into a post-MI rat heart will result in better functional outcomes than each intervention alone. A photopolymerizable, biodegradable, PEGylated-fibrinogen (PF) hydrogel matrix was used as the carrier for the cardiomyocytes [neonatal rat ventricular cardiomyocytes (NRVCMs) or human embryonic stem cell-derived cardiomyocytes (hESC-CMs)]. Infarcted rat hearts (LAD ligation) were randomized to injection of saline, NRVCMs, biopolymer, or combined biopolymer-cell delivery. Echocardiography revealed typical post-infarction remodeling after 30 days in the saline-injected control group [deterioration of fractional shortening (FS) by 31.0 ± ۳.۶%]. Injection of NRVCMs or PF alone significantly (p < ۰.۰۱) altered this remodeling process (sligh
امتیاز شما:
(No Ratings Yet)
Back To Top